Interplay between post-myocardial infarction ejection fraction and atrial fibrillation: implications for ischemic stroke
نویسندگان
چکیده
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Singapore Ministry Health’s Medical Research Council Background There are little data on the interplay between post-acute myocardial infarction (MI), left ventricular systolic dysfunction and atrial fibrillation (AF) impact subsequent acute ischemic stroke (AIS), particularly among patients with moderately reduced ejection fraction (EF). Purpose We aimed to study association low EF, AF risk severity AIS. Methods This linked national, population-based from Myocardial Infarction Registry Stroke 2007 2018. The EF status were recorded during index MI hospitalization. Patients grouped based an ≥50% or <50%. An additional grouping AMI in 2008 2018 (normal EF), 40-49% (mildly EF) <40% (reduced was done. primary outcome interest developing AIS after AMI. secondary Institute Health Scale (NIHSS) across different strata Results 64512 available for analysis. median age 65.7 69.5% male. duration 16.9 (IQR 1.6-46.1) months. Low independently associated (adjusted HR 1.18, 95% CI 1.10-1.27), as 1.16, 1.06-1.27). Among AF, EF<50% not a statistically significant predictor 1.08, 0.96-1.23). In without mildly group had increased aHR 1.18 (95% 1.06-1.31), but those (aHR 1.03, 0.87-1.23). cubic spline curves continuous against relative hazard stratified by presence is shown Figure 1. highest NIHSS score (EF 6-9; 4; 4). Conclusions Reduced post-MI AF. Further research needed mitigate late along
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2023
ISSN: ['2634-3916']
DOI: https://doi.org/10.1093/eurheartj/ehac779.060